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This web-server finds an optimal minimal distance global alignment of two amino acid sequences based on the comparison of the profiles of biochemical properties of these sequences. Unlike traditional amino acid sequence alignment methods that use a fixed 20x20 matrix to score matches and mismatches, SP2ALIGN measures the distance between pairs of aligned residues using a set of weighted biochemical properties of amino acids. The user can provide any number of amino acid properties (such as hydrophobicity, size, charge, etc) and specify a weight for each property. The higher the weight for a given property, the more this property affects the final alignment. For more details please refer to the help link.
Use the amino acid properties listed below:
Hydrophobicity with the weight of:
Size with the weight of:
Coil propensity with the weight of:
Presence of thiol group with the weight of:
OR Upload a file with amino acid properties:
Normalize amino acid properties: Yes No
Please address your questions and comments to Igor Kuznetsov Web-design: Michael McDuffie
